Chiefs vs. 49ers NFL Week 7 Picks: Kansas City Will Stay Undefeated

Chiefs Lean on Stars to Defeat Saints

Meanwhile, in Kansas City, the Chiefs turned to their veteran stars to stay unbeaten with a 26-13 win over the Saints on October 7. Patrick Mahomes passed for 331 yards, Travis Kelce led the team with nine catches for 70 yards, and Kareem Hunt, back in a Chiefs uniform, rushed for 102 yards and a touchdown on 27 carries.

Kansas City’s defense made its mark, holding Saints quarterback Derek Carr to 185 yards, two touchdowns, and one interception before he left the game with an oblique injury after taking a hit from Chamarri Conner on a failed fourth-down play. The injury dashed New Orleans’ comeback hopes as they trailed 23-13 with just under 10 minutes remaining.

Saints running back Alvin Kamara struggled to find space, tallying only 26 rushing yards on 11 carries. Kansas City’s defense, which had already stymied top rushers like Derrick Henry, Zack Moss, Bijan Robinson, and J.K. Dobbins in recent weeks, once again proved impenetrable.

San Francisco Gets Much-Needed Win

Brock Purdy threw for 255 yards and three touchdowns, guiding the 49ers to a 36-24 victory over the Seahawks on October 10, where San Francisco never relinquished the lead.

Deebo Samuel electrified with a 76-yard catch-and-run touchdown, contributing three catches for 102 yards, as the defending NFC champions pulled even with Seattle atop the NFC West standings after a rocky start to the season.

George Kittle chipped in with five receptions for 58 yards and two touchdowns, extending San Francisco’s dominance over Seattle to six straight victories. Kyle Juszczyk added a late rushing touchdown, and both he and Kittle celebrated by jumping into the stands to embrace their wives, seated together in the front row.

Just four days after squandering a 23-10 halftime lead and falling to division rival Arizona, the 49ers held off a push from Seattle in the second half to secure the win.

Key Matchups

This game features two of the league’s premier teams, both boasting dynamic playmakers on offense and defenses capable of stifling opponents.

Kansas City’s offense, powered by the reliable connection between Mahomes and Kelce, continues to hum along as they remain unbeaten. On the other hand, San Francisco has regained its footing after an uneven start to the season, with Purdy leading a balanced attack.

The game will likely come down to how effectively San Francisco’s defense can slow down Mahomes while finding consistent production from Purdy and their weapons.

Patrick Mahomes and Travis Kelce vs. 49ers’ Secondary

Mahomes’ ability to extend plays and find Kelce in crucial moments has been the backbone of Kansas City’s success. With Mahomes throwing for 331 yards in his last outing, the 49ers’ defense, which has struggled at times, will have to tighten up in coverage.

Look for the Chiefs to try to exploit mismatches with Kelce over the middle, but San Francisco’s defense, known for its physicality, must prevent Kelce from dominating the short-to-intermediate game. If they can limit Kelce’s impact, they could disrupt Mahomes’ rhythm.

Brock Purdy vs. Chiefs’ Defense

Purdy has been efficient in his role, throwing for 255 yards and three touchdowns in his last game, but he’ll face a tough test against a Kansas City defense that has consistently shut down top running backs and forced opposing offenses to become one-dimensional.

If Purdy can spread the ball effectively to Samuel and Kittle, he’ll give San Francisco a chance to keep pace. The Chiefs, however, are adept at getting pressure and forcing mistakes, so Purdy will need to be sharp and avoid turnovers.

49ers’ Rushing Attack vs. Chiefs’ Run Defense

San Francisco has the ability to strike through the air, but their ground game adds balance. The Chiefs’ defense, which stymied Kamara to just 26 yards, will be looking to shut down the 49ers’ rushing attack in a similar manner.

If San Francisco can establish the run early, it will open up opportunities for Purdy to hit playmakers like Samuel and Kittle downfield. However, if Kansas City’s defense continues its trend of smothering opposing run games, it could force the 49ers into an uncomfortable situation.

Special Teams and Turnovers

In a battle between two well-rounded teams, turnovers and special teams could tilt the balance. The Chiefs have been opportunistic, creating key turnovers, including pressuring Carr into a costly interception last week. On the other side, the 49ers’ defense has shown resilience after their collapse against Arizona. Whichever team wins the turnover battle is likely to come out on top.

The Pick

This game promises to be a hard-fought, back-and-forth contest. Kansas City’s ability to keep its offense humming, combined with a strong defensive showing, could pose problems for San Francisco, especially if the Chiefs’ run defense stifles the 49ers’ ground game early.

However, if Purdy and the 49ers can establish some offensive balance and slow down Mahomes’ connection with Kelce, they will have a chance to pull off a close win.

Ultimately, Mahomes’ experience in tight games, along with Kelce’s ability to find space against any defense, should give Kansas City the edge in this game. Purdy and the 49ers will fight hard, but the Chiefs’ defense and Mahomes’ late-game heroics will make the difference.

NFL Pick: Chiefs ML (+100) at Bovada

Chiefs ML (+100)

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